Human IgG4 Isotype Control Antibody

Customer Review

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David Walker
09.Sep,23

Excellent for IgG4 Control

The Human IgG4 Isotype Control Antibody has been excellent for our IgG4 control studies. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.

Emily Turner
11.Oct,22

Reliable in Immunoassays

We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for IgG4 is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.

John Harris
20.Jul,21

Consistent and High-Quality

This antibody has proven to be consistent and high-quality in our assays. The reproducible results and strong affinity for IgG4 have significantly improved our experiments, making it a crucial part of our research toolkit. The consistent performance has greatly enhanced our data quality.

Q&As

1. Is the Human IgG4 isotype control antibody suitable for use in flow cytometry?

   A: Yes, the Human IgG4 isotype control antibody (MOB-0408ZL) is suitable for use in flow cytometry. It provides an appropriate control for determining the level of non-specific binding in flow cytometry assays.

2. What are the storage recommendations for the Human IgG4 isotype control antibody?

   A: The recommended storage condition for the Human IgG4 isotype control antibody (MOB-0408ZL) is at -20°C or lower. For short-term storage, it can be kept at 2-8°C. To ensure stability, avoid repeated freeze-thaw cycles.

3. Can the Human IgG4 isotype control antibody be used in immunoprecipitation assays?

   A: Yes, the Human IgG4 isotype control antibody (MOB-0408ZL) can be used in immunoprecipitation assays. It provides an appropriate control for determining the level of non-specific binding in such assays.

4. Is the Human IgG4 isotype control antibody effective in ELISA applications?

   A: Yes, the Human IgG4 isotype control antibody (MOB-0408ZL) is effective in ELISA applications. It provides an appropriate control for determining the level of non-specific binding in ELISA assays.

5. What is the optimal dilution for using the Human IgG4 isotype control antibody in immunofluorescence?

   A: The optimal dilution for using the Human IgG4 isotype control antibody (MOB-0408ZL) in immunofluorescence is typically 1:100 to 1:500. It is advisable to perform a dilution series to determine the best working concentration for your specific experimental conditions.

View the frequently asked questions answered by Creative Biolabs Support.

Citations

1. Choi, Seong Jin, et al. "KIR+ CD8+ and NKG2A+ CD8+ T cells are distinct innate-like populations in humans." Cell Reports 42.3 (2023). https://doi.org/10.1016/j.celrep.2023.112236
   This study explores the heterogeneity among human KIR+CD8+ and NKG2A+CD8+ T cells, identifying them as distinct innate-like populations with different cytokine responsiveness. The research demonstrates that KIR+CD8+ T cells exhibit IL-15-induced NK-like cytotoxicity, while NKG2A+CD8+ T cells show IL-12/IL-18-induced IFN-gamma production. It was observed that KIR+CD8+ T cells are more terminally differentiated and replicative senescent compared to NKG2A+CD8+ T cells, which are more responsive to IL-12 and IL-18 due to the high expression of these receptors induced by the transcription factor PLZF.
   At Creative Biolabs, we provided essential reagents for this study, including the anti-NKG2A antibody (Cat#: TAB-437CQ) and the IgG4 isotype control (Cat# MOB-0408ZL) used in the flow cytometry analyses. Our products were crucial in identifying the distinct functional roles and cytokine responses of these T cell subsets. This research underscores the importance of understanding the diverse functions of T cell populations in developing targeted immunotherapies, highlighting our commitment to advancing immunological research and innovative therapeutic solutions.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# MOB-0408ZL, RRID: AB_3111477)

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

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COA

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Protocol & Troubleshooting

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.